1 | UNIVERSITY OF HEALTH SCIENCES, ŞANLIURFA MEHMET AKIF İNAN EDUCATION AND RESEARCH HOSPITAL, DEPARTMENT OF PATHOLOGY, HALILIYE, ŞANLIURFA, TURKEY |
Abstract
Objective. We aimed to demonstrate whether the immunohistochemical expression of C-erb-B2 and progesterone receptors are valuable in the diagnosis of intraepithelial cervical neoplasia and squamous cell carcinoma. Methods and Results. Our retrospective study, a total of 84 cases diagnosed as squamous cell carcinoma and cervical intraepithelial neoplasia during 2005-2009, at the pathology department of Harran University, was investigated and stained with immunohistochemistry. Progesterone receptor was stained positive in 5 of 21 cervical intraepithelial neoplasia I. As a result of the statistical analysis (SPSS statistic 15.0), a significant correlation was found for positive progesterone receptors. No positive staining was seen in any of the cases with CerbB2 (p>0,05). Conclusions. In this study, it was concluded that positive progesterone receptors can be used to distinguish cases of cervical intraepithelial neoplasia I from other dysplasia and carcinoma, while Cerb-B2 has not been shown to be useful in distinguishing between these lesions.
Cite this article:
Vancouver | Tarini ZE, Özardali İH. Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia. J Clin Investig Surg. 2021 May 25;6(1):43-47. Available from: https://www.proscholar.org/jcis/archive/vol.6/iss.1/8/ doi: 10.25083/2559.5555/6.1.8 |
NLM | Tarini ZE, Özardali İH. Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia. J Clin Investig Surg. 2021 May;6(1):43-47. doi: 10.25083/2559.5555/6.1.8. |
AMA | Tarini ZE, Özardali İH. Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia. J Clin Investig Surg. 2021;6(1):43-47. |
MLA | Tarini, Zeynep E and Özardali, İlyas H. “Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia.” Journal of Clinical and Investigative Surgery 6.1 (2021): 43-47. doi:10.25083/2559.5555/6.1.8. |
APA | Tarini, Z. E., & Özardali, İ. H. (2021). Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia. Journal of Clinical and Investigative Surgery, 6(1), 43-47. |
ISO 690 | Tarini , Zeynep E and Özardali , İlyas H. Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia. Journal of Clinical and Investigative Surgery, 2021, 6.1: 43-47. |