HomeArchiveVolume 7Volume 7, issue 1Accuracy of C-reactive protein and leukocyte count in the diagnosis of acute appendicitis compared to histopathological examination
N. Rajashekar1, Satish Ammapalem1, Reddy Prashanth1, C.Y. Vidyadhar1
1DEPARTMENT OF GENERAL SURGERY, PES INSTITUTE OF MEDICAL SCIENCES AND RESEARCH (PESIMSR), KUPPAM, ANDHRA PRADESH, INDIA
Abstract
Background. One of the most common causes of acute surgical abdomen is acute appendicitis. The aim of this study was to compare the accuracy of C-reactive protein (CRP) and the total leukocyte count (TLC) with the postoperative histopathological examination in the diagnosis of acute appendicitis. Methods. It is a prospective observational study over a period of 18 months, on patients who underwent emergency appendectomy. Purposive sampling method and Chi square test were used for the study to find significant association between the variables. Results. The mean age of the participants was 24.06 ± 8.61 years (74.7% men and 25.3% women). All cases had abdominal pain, and 86.7% anorexia, 57.3% migraine, 49.3% vomiting, 38.7% fever. In the case of the normal appendix, TLC was positive in 31% of cases; in cases with inflamed appendix 65% of cases were positive for TLC, while in cases with gangrenous and/or perforated appendix all cases were positive for TLC. CRP had a sensitivity of 88.7%, 69.23% specificity, 93.22% PPV and 56.25% NPV for diagnosis. When both TLC and CRP were used, they have a high sensitivity (90.32%) compared to single use and reported to histopathological findings, and a high PPV value (93.33%). Conclusions. The combined sensitivity and specificity values of TLC and CRP were higher in the diagnosis of acute appendicitis, thus reducing the number of negative appendicectomies and the need for a CT scan, which is generally expensive and associated with the risk of radiation.
Cite this article:
Vancouver
Rajashekar N, Ammapalem S, Prashanth R, Vidyadhar C. Accuracy of C-reactive protein and leukocyte count in the diagnosis of acute appendicitis compared to histopathological examination. J Clin Investig Surg. 2022 May 25; 7(1):62-66. Available from: https://www.proscholar.org/jcis/archive/vol.7/iss.1/11/ doi: 10.25083/2559.5555/7.1.11
NLM
Rajashekar N, Ammapalem S, Prashanth R, Vidyadhar C. Accuracy of C-reactive protein and leukocyte count in the diagnosis of acute appendicitis compared to histopathological examination. J Clin Investig Surg. 2022 May;7(1):62-66. doi: 10.25083/2559.5555/7.1.11.
AMA
Rajashekar N, Ammapalem S, Prashanth R, Vidyadhar C. Accuracy of C-reactive protein and leukocyte count in the diagnosis of acute appendicitis compared to histopathological examination. J Clin Investig Surg. 2022;7(1):62-66.
MLA
Rajashekar, N., et al. “Accuracy of C-reactive protein and leukocyte count in the diagnosis of acute appendicitis compared to histopathological examination.” Journal of Clinical and Investigative Surgery 7.1 (2022): 62-66. doi:10.25083/2559.5555/7.1.11.
APA
Rajashekar, N., Ammapalem, S., Prashanth, R., & Vidyadhar, C. (2022). Accuracy of C-reactive protein and leukocyte count in the diagnosis of acute appendicitis compared to histopathological examination. Journal of Clinical and Investigative Surgery, 7(1), 62-66.
ISO 690
Rajashekar
, N., et al. Accuracy of C-reactive protein and leukocyte count in the diagnosis of acute appendicitis compared to histopathological examination. Journal of Clinical and Investigative Surgery, 2022, 7.1: 62-66.