Journal of Clinical and Investigative Surgery
ISSN: 2559-5555


Indocyanine green enhanced surgery; principle, clinical applications and future research directions

Catalin Alius1,3, Sorin Oprescu1,3, Cristian Balalau2,3, Adriana Elena Nica1,3

1Bucharest University Emergency Hospital, Bucharest, Romania
2St. Pantelimon Emergency Hospital, Department of General Surgery, Bucharest, Romania
3Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

J Clin Invest Surg. 2018; 3(1): 1-8. DOI: 10.25083/2559.5555/31.18
Running title: Indocyanine green enhanced surgery
Keywords: indocyanine green, surgery, near infrared fluorescence


Over the past decade a new emergent technology has become very popular in all fields of surgery using Indocyanine green and near infrared fluorescent optical systems. This revolutionary approach overlaps conventional and near infrared images to produce highly informative intraoperative images on the anatomy and physiology of various tissues.

Near infrared fluorescence is employed for perioperative angiography in vascular mapping, assessment of anastomoses, location of sentinel lymph nodes and delineation of biliary tree anatomy, highlighting tumours and metastatic deposits, improving surgical techniques and for many other uses.

A lot of researchers have reported better surgical outcomes and technique innovations facilitated by this novel technology which although in its early stages, it lights up great interest worldwide.

This article reviews the principle of the method, the properties of the fluorescent dye, the main clinical applications and discusses future research directions.