Journal of Clinical and Investigative Surgery
ISSN: 2559-5555


Subcutaneous metastasis from endometrial cancer; case report and literature review

Nicolae Bacalbasa1,2, Irina Balescu3, Alexandru Filipescu1,4

1Carol Davila University of Medicine and Pharmacy, Department of Obstetrics and Gynecology, Bucharest, Romania
2Fundeni Clinical Institute, Center of Excellence in Translational Medicine, Bucharest, Romania
3Ponderas Academic Hospital, Department of General Surgery, Bucharest, Romania
4Elias Hospital, Department of Obstetrics and Gynecology, Bucharest, Romania

J Clin Invest Surg. 2018; 3(1): 37-41. DOI: 10.25083/2559.5555/31.3741
Running title: Subcutaneous metastasis from endometrial cancer
Keywords: endometrial cancer, distant metastasis, subcutaneous lesion


Subcutaneous metastases from endometrial cancer are rare situations, only few cases being described so far. The main incriminated mechanisms leading to the apparition of such lesions include hematogenous and lymphatic spread. We present the case of a 66-year-old patient known with previous history of stage IIIA endometroid endometrial carcinoma initially treated by surgery and adjuvant chemotherapy who developed at 18 months follow-up a distant subcutaneous oligometastasis. At this time the patient was resubmitted to surgery, the lesion being successfully removed. The histopathological result confirmed the endometrial cancer origin of this lesion.

Subcutaneous and cutaneous metastases from endometrial cancer are rare eventualities which are usually diagnosed as part of systemic dissemination of this malignancy; in these cases, the patient is only candidate for oncological treatment with palliative intent. In some cases, in which the lesions occur as oligometastatic disease, surgery might be performed with curative intent. In our case the diagnostic of the subcutaneous lesion as oligometastatic disease transformed the patient in a perfect candidate for curative oncological surgery.