Journal of Clinical and Investigative Surgery
Cornelia Nitipir1,2, Cristina Orlov2, Ana-Maria Popa2, Iulian Slavu1, Adrian Tulin1,3
1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2Elias University Emergency Hospital, Department of Oncology, Bucharest, Romania
3Agrippa Ionescu Emergency Hospital, Department of General Surgery, Bucharest, Romania
Objective. The purpose of this paper is to review the current concepts in the literature regarding the beneficial effects of adjuvant surgery after concurrent radio-chemotherapy for locally advanced cervical cancer.
Method. Research of the literature was performed using PubMed databases in order to find articles relevant to the central topic. The PICOS criteria were used to filter the results. The paper was then structured according to the PRISMA guideline.
Results. 50 individual papers were analyzed and sorted according to their relevance for the topic. 18 were classified as relevant. There was little agreement as to how beneficial adjuvant hysterectomy is in locally advanced cervical cancer after chemoradiotherapy. Some articles concluded that patients with a total clinical response after initial treatment might have superior progression-free survival and overall survival after surgery. 2 articles underlined the importance of accurate restaging after primary treatment. The lack of benefit for surgery in patients with bulky disease or persistent adenopathies was agreed upon in all cases.
Conclusions. The decision for adjuvant hysterectomy with or without lymphadenectomy is a controversial one and has to be personalized and taken in a multidisciplinary team.