Journal of Clinical and Investigative Surgery
ISSN: 2559-5555


Is there a place for liver transplantation in cases with unresectable central cholangiocarcinoma?

Nicolae Bacalbașa1,2,3, Irina Balescu4, Mihaela Vilcu2,3, Iulian Brezean2,3, Alin Bodog5

1Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania
2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
3Ion Cantacuzino Clinical Hospital, Bucharest, Romania
4Ponderas Academic Hospital, Bucharest, Romania
5Oradea Medical University, Oradea, Romania

J Clin Invest Surg. 2018; 3(2): 57-61. DOI: 10.25083/2559.5555/3.2/57.61
Running title: Liver transplantation for unresectable cholangiocarcinoma
Keywords: unresectable, central cholangiocarcinoma, liver transplantation


Central cholangiocarcinoma represents a very aggressive malignancy associated with poor survival rats especially due to the fact that most patients are diagnosed in advanced stages of the disease when curative resection is no longer feasible. In order to try improving the long-term outcomes of these patients, especially in unresectable cases liver transplantation has been proposed with promising results. This is a literature review of the largest studies focused on this subject.

Cholangiocarcinomas remain aggressive tumors with poor outcomes whenever surgery with curative intent is not feasible. Currently, the largest experience accumulated consists of neoadjuvant external beam radiotherapy in association with beam radiation, 5 fluorouracil and capecitabine followed by orthotopic liver transplantation. Following this therapeutic protocol excellent long-term outcomes have been reported even if vascular involvement is present.