{"id":860,"date":"2021-07-20T05:58:08","date_gmt":"2021-07-20T05:58:08","guid":{"rendered":"https:\/\/www.proscholar.org\/jcis\/?page_id=860"},"modified":"2021-07-20T05:58:08","modified_gmt":"2021-07-20T05:58:08","slug":"1","status":"publish","type":"page","link":"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/","title":{"rendered":"Volume 3, issue 2, pp. 57-61"},"content":{"rendered":"<p class=\"withindent\">Central cholangiocarcinoma represents a very aggressive malignancy associated with poor survival rats especially due to the fact that most patients are diagnosed in advanced stages of the disease when curative resection is no longer feasible. In order to try improving the long-term outcomes of these patients, especially in unresectable cases liver transplantation has been proposed with promising results. This is a literature review of the largest studies focused on this subject.<\/p>\n<p class=\"withindent\">Cholangiocarcinomas remain aggressive tumors with poor outcomes whenever surgery with curative intent is not feasible. Currently, the largest experience accumulated consists of neoadjuvant external beam radiotherapy in association with beam radiation, 5 fluorouracil and capecitabine followed by orthotopic liver transplantation. Following this therapeutic protocol excellent long-term outcomes have been reported even if vascular involvement is present.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Central cholangiocarcinoma represents a very aggressive malignancy associated with poor survival rats especially due to the fact that most patients are diagnosed in advanced stages of the disease when curative resection is no longer feasible. In order to try improving the long-term outcomes of these patients, especially in unresectable cases liver transplantation has been proposed [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":805,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"publication_category":[6],"class_list":["post-860","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Volume 3, issue 2, pp. 57-61 - Journal of Clinical and Investigative Surgery<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Volume 3, issue 2, pp. 57-61 - Journal of Clinical and Investigative Surgery\" \/>\n<meta property=\"og:description\" content=\"Central cholangiocarcinoma represents a very aggressive malignancy associated with poor survival rats especially due to the fact that most patients are diagnosed in advanced stages of the disease when curative resection is no longer feasible. In order to try improving the long-term outcomes of these patients, especially in unresectable cases liver transplantation has been proposed [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/\" \/>\n<meta property=\"og:site_name\" content=\"Journal of Clinical and Investigative Surgery\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/\",\"url\":\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/\",\"name\":\"Volume 3, issue 2, pp. 57-61 - Journal of Clinical and Investigative Surgery\",\"isPartOf\":{\"@id\":\"https:\/\/www.proscholar.org\/jcis\/#website\"},\"datePublished\":\"2021-07-20T05:58:08+00:00\",\"dateModified\":\"2021-07-20T05:58:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.proscholar.org\/jcis\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/www.proscholar.org\/jcis\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Volume 3\",\"item\":\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Volume 3, issue 2\",\"item\":\"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Volume 3, issue 2, pp. 57-61\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.proscholar.org\/jcis\/#website\",\"url\":\"https:\/\/www.proscholar.org\/jcis\/\",\"name\":\"Journal of Clinical and Investigative Surgery\",\"description\":\"JCIS\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.proscholar.org\/jcis\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Volume 3, issue 2, pp. 57-61 - Journal of Clinical and Investigative Surgery","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.proscholar.org\/jcis\/publications\/vol.3\/iss.2\/1\/","og_locale":"en_US","og_type":"article","og_title":"Volume 3, issue 2, pp. 57-61 - Journal of Clinical and Investigative Surgery","og_description":"Central cholangiocarcinoma represents a very aggressive malignancy associated with poor survival rats especially due to the fact that most patients are diagnosed in advanced stages of the disease when curative resection is no longer feasible. 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