HomeArchiveVolume 7Volume 7, issue 1The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children
Mehmet Altuntaș1, Gürkan Altuntaş1, Ahmet S. Calapoğlu2, Recep Bedir3, Mehtap Atak4
1Recep Tayyip Erdogan University, Faculty of Medicine, Department of Emergency Medicine, Rize, Turkey
2Recep Tayyip Erdogan University, Faculty of Medicine. Department of Pediatric Surgery, Rize, Turkey
3Recep Tayyip Erdogan University, Faculty of Medicine. Department of Pathology, Rize, Turkey
4Recep Tayyip Erdogan University, Faculty of Medicine, Department of Medical Biochemistry, Rize, Turkey
Abstract
Objectives. This study aims to show the clinical value of ischemia-modified albumin (IMA) and Signal Peptide, Complementary C1r/C1s, Uegf and Bmp1–Epidermal Growth Factor Like Domain Containing 1 (SCUBE1) protein in pediatric appendicitis. Methods. Eighty-one pediatric patients hospitalized in the pediatric surgery ward with acute appendicitis and a control group of 62 pediatric patients with unspecific abdominal pain were included in this prospective case-control study. Thirty-nine patients whose pathology specimens confirmed acute appendicitis made up the final appendicitis group. Results. Patients with appendicitis had higher IMA (p<0.001) and SCUBE1 (p<0.001) levels than the control group. In receiver operating characteristic (ROC) analysis, areas under the curve (AUC) were 0.991 (sensitivity=97.4%, specifity=100%, positive likelihood ratio (+LR) infinity, negative likelihood ratio (-LR)=0.03, positive predictive values (+PV)=100%, negative predictive value (-PV)=98.3% for IMA and 0.803 (sensitivity = 89.7%, specificity =64.5%, +LR=2.53, -LR=0.16, +PV=61.4%, -PV=90.9%) for SCUBE1. Conclusions. The present study shows that IMA may be a reliable marker for a more accurate diagnosis of appendicitis. SCUBE1 can be used to exclude diagnosis if used in combination with other laboratory and clinical data.
Cite this article:
Vancouver
Altuntaș M, Altuntaş G, Calapoğlu AS, Bedir R, Atak M. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. J Clin Investig Surg. 2022 May 25; 7(1):1-7. Available from: https://www.proscholar.org/jcis/archive/vol.7/iss.1/1/ doi: 10.25083/2559.5555/7.1.1
NLM
Altuntaș M, Altuntaş G, Calapoğlu AS, Bedir R, Atak M. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. J Clin Investig Surg. 2022 May;7(1):1-7. doi: 10.25083/2559.5555/7.1.1.
AMA
Altuntaș M, Altuntaş G, Calapoğlu AS, Bedir R, Atak M. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. J Clin Investig Surg. 2022;7(1):1-7.
MLA
Altuntaș, Mehmet, et al. “The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children.” Journal of Clinical and Investigative Surgery 7.1 (2022): 1-7. doi:10.25083/2559.5555/7.1.1.
APA
Altuntaș, M., Altuntaş, G., Calapoğlu, A. S., Bedir, R., & Atak, M. (2022). The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. Journal of Clinical and Investigative Surgery, 7(1), 1-7.
ISO 690
Altuntaș
, Mehmet, et al. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. Journal of Clinical and Investigative Surgery, 2022, 7.1: 1-7.