1 | Recep Tayyip Erdogan University, Faculty of Medicine, Department of Emergency Medicine, Rize, Turkey |
2 | Recep Tayyip Erdogan University, Faculty of Medicine. Department of Pediatric Surgery, Rize, Turkey |
3 | Recep Tayyip Erdogan University, Faculty of Medicine. Department of Pathology, Rize, Turkey |
4 | Recep Tayyip Erdogan University, Faculty of Medicine, Department of Medical Biochemistry, Rize, Turkey |
Abstract
Objectives. This study aims to show the clinical value of ischemia-modified albumin (IMA) and Signal Peptide, Complementary C1r/C1s, Uegf and Bmp1–Epidermal Growth Factor Like Domain Containing 1 (SCUBE1) protein in pediatric appendicitis. Methods. Eighty-one pediatric patients hospitalized in the pediatric surgery ward with acute appendicitis and a control group of 62 pediatric patients with unspecific abdominal pain were included in this prospective case-control study. Thirty-nine patients whose pathology specimens confirmed acute appendicitis made up the final appendicitis group. Results. Patients with appendicitis had higher IMA (p<0.001) and SCUBE1 (p<0.001) levels than the control group. In receiver operating characteristic (ROC) analysis, areas under the curve (AUC) were 0.991 (sensitivity=97.4%, specifity=100%, positive likelihood ratio (+LR) infinity, negative likelihood ratio (-LR)=0.03, positive predictive values (+PV)=100%, negative predictive value (-PV)=98.3% for IMA and 0.803 (sensitivity = 89.7%, specificity =64.5%, +LR=2.53, -LR=0.16, +PV=61.4%, -PV=90.9%) for SCUBE1. Conclusions. The present study shows that IMA may be a reliable marker for a more accurate diagnosis of appendicitis. SCUBE1 can be used to exclude diagnosis if used in combination with other laboratory and clinical data.
Cite this article:
Vancouver | Altuntaș M, Altuntaş G, Calapoğlu AS, Bedir R, Atak M. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. J Clin Investig Surg. 2022 May 25;7(1):1-7. Available from: https://www.proscholar.org/jcis/archive/vol.7/iss.1/1/ doi: 10.25083/2559.5555/7.1.1 |
NLM | Altuntaș M, Altuntaş G, Calapoğlu AS, Bedir R, Atak M. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. J Clin Investig Surg. 2022 May;7(1):1-7. doi: 10.25083/2559.5555/7.1.1. |
AMA | Altuntaș M, Altuntaş G, Calapoğlu AS, Bedir R, Atak M. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. J Clin Investig Surg. 2022;7(1):1-7. |
MLA | Altuntaș, Mehmet, et al. “The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children.” Journal of Clinical and Investigative Surgery 7.1 (2022): 1-7. doi:10.25083/2559.5555/7.1.1. |
APA | Altuntaș, M., Altuntaş, G., Calapoğlu, A. S., Bedir, R., & Atak, M. (2022). The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. Journal of Clinical and Investigative Surgery, 7(1), 1-7. |
ISO 690 | Altuntaș , Mehmet, et al. The clinical value of IMA and SCUBE1 in the diagnosis of acute appendicitis in children. Journal of Clinical and Investigative Surgery, 2022, 7.1: 1-7. |